Lin Chen

Lin Chen

Associate Professor

Publications

D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

Published in Journal of Cerebral Blood Flow and Metabolism, 2020

Functioning of the glucose transporter and glymphatic systems in the tauopathy AD mouse brain studied by onVDMP MRI and D-glucose infusion

Recommended citation: Chen L, Wei Z, Chan KWY, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PCM, Li T, Xu J. D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI. Journal of Cerebral Blood Flow and Metabolism 2020; https://doi.org/10.1177/0271678X20941264

High-sensitivity CEST mapping using a spatiotemporal correlation-enhanced method

Published in Magnetic Resonance in Medicine, 2020

MLSVD CEST provides a simple and efficient way to improve the SNR of CEST images.

Recommended citation: Chen L, Cao S, Koehler RC, van Zijl PCM, Xu J. High-sensitivity CEST mapping using a spatiotemporal correlation-enhanced method. Magn Reson Med 2020; https://doi.org/10.1002/mrm.28380

In vivo imaging of phosphocreatine with artificial neural networks

Published in Nature Communications, 2020

Phosphocreatine plays a vital role in cellular energetic homeostasis, but there are no routine diagnostic tests to noninvasively map the distribution with clinically relevant spatial resolution. Here, we develop and validate a noninvasive approach for quantifying and imaging phosphocreatine, without contrast agents, on widely available clinical MRI scanners with artificial neural networks.

Recommended citation: Chen L, Schar M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss RG, van Zijl PCM, Xu J. In vivo imaging of phosphocreatine with artificial neural networks. Nature Communications 2020;11(1):1072.

High-resolution creatine mapping of mouse brain at 11.7 T using non-steady-state chemical exchange saturation transfer

Published in NMR in Biomedicine, 2019

High-resolution creatine map can be obtained on mouse brain using polynomial and Lorentzian line-shape fitting (PLOF) method with non-steady-state CEST acquisition.

Recommended citation: Chen L, Wei Z, Cai S, Li Y, Liu G, Lu H, Weiss RG, van Zijl PCM, Xu J. High-resolution creatine mapping of mouse brain at 11.7 T using non-steady-state chemical exchange saturation transfer. NMR in Biomedicine. 2019;e4168.

Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method

Published in Magnetic Resonance in Medicine, 2018

High-resolution Cr and PCr maps of mouse skeletal muscle can be obtained using a polynomial and Lorentzian line-shape fitting (PLOF) CEST method.

Recommended citation: Chen L, Barker PB, Weiss RG, van Zijl PCM, Xu J. Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method. Magn Reson Med 2019;81(1):69-78.

Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse(VDMP) MRI (Editor’s Pick)

Published in Magnetic Resonance in Medicine, 2018

Develop a method that can separate and quantify the fast (>1 kHz) and slow exchange transfer and magnetization transfer components in Z-spectra.

Recommended citation: Chen L, Xu X, Zeng H, Chan KWY, Yadav N, Cai S, Schunke KJ, Faraday N, van Zijl PCM, Xu J. Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI. Magn Reson Med 2018;80(4):1568-1576.

Investigation of the contribution of total creatine to the CEST Z-spectrum of brain using a knockout mouse model

Published in NMR in Biomedicine, 2017

The current study aims to assign and estimate the total creatine (tCr) signal contribution to the Z-spectrum in mouse brain at 11.7 T.

Recommended citation: Chen L, Zeng H, Xu X, Yadav NN, Cai S, Puts NA, Barker PB, Li T, Weiss RG, van Zijl PCM, Xu J. Investigation of the contribution of total creatine to the CEST Z-spectrum of brain using a knockout mouse model. NMR Biomed 2017;30(12):e3834.

Variable density sampling and non-Cartesian super-resolved reconstruction for spatiotemporally encoded single-shot MRI (Cover article)

Published in Journal of Magnetic Resonance, 2016

Non-Cartesian spatiotemporally encoded (SPEN) MRI with variable density sampling and super-resolved reconstruction improves imaging's faithfulness and spatial resolution.

Recommended citation: Chen L, Huang J, Zhang T, Li J, Cai C, Cai S. Variable density sampling and non-Cartesian super-resolved reconstruction for spatiotemporally encoded single-shot MRI. J Magn Reson 2016;272:1-9.

Super-resolved enhancing and edge deghosting (SEED) for spatiotemporally encoded single-shot MRI

Published in Medical Image Analysis, 2015

Super-resolved enhancing and edge deghosting (SEED) is the state-of-the-art super-resolved method for spatiotemporally encoded (SPEN) single-shot MRI

Recommended citation: Chen L, Li J, Zhang M, Cai S, Zhang T, Cai C, Chen Z. Super-resolved enhancing and edge deghosting (SEED) for spatiotemporally encoded single-shot MRI. Med Image Anal 2015;23(1):1-14.