Dr. Lin Chen (陈林)

Biography

Dr. Chen received his B.S., M.S. and Ph.D. degrees from Xiamen University. His dissertation focused on spatiotemporally encoded (SPEN) single-shot MRI and chemical exchange saturation transfer (CEST) MRI. During his Ph.D. program, he joined Peter van Zijl’s group as Visiting Student at Johns Hopkins University School of Medicine. After completing Ph.D. program, he joined Johns Hopkins University as a postdoctoral fellow in 2018. His current interest is developing new methods for CEST MRI.

Education

• B.S. in Electronic Information Science and Technology, Xiamen University, 2011
• M.S. in Electronics and Communication Engineering, Xiamen University, 2014
• Ph.D. in Electromagnetic Field and Microwave Technology, Xiamen University, 2017
• Visiting Student, Johns Hopkins University, 2015 - 2017
• Postdoctoral Fellow, Johns Hopkins University, 2018 - 2020

Honors and awards

• 2020 OCSMRM Young Investigator Award First Place
• 2020 ISMRM Magna Cum Laude Merit Award
• 2019 OCSMRM Young Investigator Award Third Place
• 2019 ISMRM Summa Cum Laude Merit Award
• 2018 First Prize of the 13th Excellent Academic Paper of Natural Science in Fujian Province
• 2016 National Scholarship for Graduate Students
• 2016, 2015, 2014 ISMRM Educational Stipend
• 2015 ISMAR Best Poster Award
• 2014, 2013, 2012, 2010, 2009 Xiamen University Merit Student
• 2011 Xiamen University Outstanding Student Leader

Journal publications

1. Chen L, Schar M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss R, van Zijl PCM, Xu J. In vivo imaging of phosphocreatine with artificial neural networks. Nature Communications 2020;11(1):1072. [Find paper here]
   
2. Zhou Y, van Zijl PCM, Xu X, Xu J, Li Y, Chen L, Yadav NN. Magnetic resonance imaging of glycogen using its magnetic coupling with water. Proc Natl Acad Sci USA 2020;117(6),3144-3149.
   
3. Huang J, van Zijl PCM, Han X, Dong CM, Cheng GWY, Tse K, Knutsson L, Chen L, Lai JHC, Wu EX, Xu J, Chan KWY. Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose enhanced MRI. Science advances 2020;6(20):eaba3884.
   
4. Chen L*, Cao S, Koehler RC, van Zijl PCM, Xu J. High-sensitivity CEST mapping using a spatiotemporal correlation-enhanced method. Magn Reson Med 2020; https://doi.org/10.1002/mrm.28380.
   
5. Chen L#, Wei Z#, Chan KWY, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PCM, Li T, Xu J. D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI. Journal of Cerebral Blood Flow & Metabolism 2020; https://doi.org/10.1177/0271678X20941264.
   
6. Chen L, Wei Z, Chan KWY, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J. Protein aggregation linked to Alzheimer’s disease revealed by saturation transfer MRI. NeuroImage 2019;188:380-390.
   
7. Chen L, Wei Z, Cai S, Li Y, Liu G, Lu H, Weiss RG, van Zijl PCM, Xu J. High-resolution creatine mapping of mouse brain at 11.7 T using non-steady-state chemical exchange saturation transfer. NMR Biomed 2019;32(11):e4168.
   
8. Chen L, Barker PB, Weiss RG, van Zijl PCM, Xu J. Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method. Magn Reson Med 2019;81(1):69-78.
   
9. Chen L, Xu X, Zeng H, Chan KWY, Yadav N, Cai S, Schunke KJ, Faraday N, van Zijl PCM, Xu J. Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI. Magn Reson Med 2018;80(4):1568-1576. (Editor’s Pick)
   
10. Chen L, Zeng H, Xu X, Yadav NN, Cai S, Puts NA, Barker PB, Li T, Weiss RG, van Zijl PCM, Xu J. Investigation of the contribution of total creatine to the CEST Z-spectrum of brain using a knockout mouse model. NMR Biomed 2017;30(12):e3834.
    
11. Chen L, Huang J, Zhang T, Li J, Cai C, Cai S. Variable density sampling and non-Cartesian super-resolved reconstruction for spatiotemporally encoded single-shot MRI. J Magn Reson 2016;272:1-9. (Cover Article)
    
12. Chen L, Li J, Zhang M, Cai S, Zhang T, Cai C, Chen Z. Super-resolved enhancing and edge deghosting (SEED) for spatiotemporally encoded single-shot MRI. Med Image Anal 2015;23(1):1-14.
    
13. Chen L, Bao L, Li J, Cai S, Cai C, Chen Z. An aliasing artifacts reducing approach with random undersampling for spatiotemporally encoded single-shot MRI. J Magn Reson 2013;237:115-124.
    
14. Ning B, Guo G, Gu C, Xu J, Bibic A, He X, Liu H,Chen L, Wei Z, Duan W, Liu P, Lu H, van Zijl PCM, Ross CA, Smith W, Hua J. Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study. Neurodegener Dis 2020:1-8.
    
15. Huang J, Han X, Chen L, Xu X, Xu J, Chan KWY. Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T. Magn Reson Med 2020; http://dx.doi.org/10.1002/mrm.28433.
    
16. Wei Z, Chen L, Hou X, van Zijl PCM, Xu J, Lu H. Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study. Frontiers in Neurology 2020;11(559)
    
17. Huang J, Chen L, Chan KWY, Cai C, Cai S, Chen Z. Super-resolved water/fat image reconstruction based on single-shot spatiotemporally encoded MRI. J Magn Reson 2020;314:106736.
    
18. Xu X, Xu J, Chan KWY, Liu J, Liu H, Li Y, Chen L, Liu G, van Zijl PCM. GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI. Magn Reson Med 2019;81(1):47-56.
    
19. Wei Z, Chen L, Lin Z, Jiang D, Xu J, Liu P, van Zijl PCM, Lu H. Optimization of phase-contrast MRI for the estimation of global cerebral blood flow of mice at 11.7T. Magn Reson Med 2019;81(4):2566-2575.
    
20. Wei Z, Xu J, Liu P, Chen L, Li W, van Zijl P, Lu H. Quantitative assessment of cerebral venous blood T2 in mouse at 11.7T: Implementation, optimization, and age effect. Magn Reson Med 2018;80(2):521-528.
    
21. Luo Y, Zhang J, Chen L, Cai S, Cai C. Accelerating multi-slice spatiotemporally encoded MRI with simultaneous echo refocusing. J Magn Reson 2018;296:12-22.
    
22. Ye Q, Chen L, Qiu W, Lin L, Sun H, Cai S, Wei Z, Chen Z. Accelerating two-dimensional nuclear magnetic resonance correlation spectroscopy via selective coherence transfer. J Chem Phys 2017;146(1):014202.
    
23. Huang J, Zhang M, Lu J, Cai C, Chen L, Cai S. A fast chemical exchange saturation transfer imaging scheme based on single-shot spatiotemporal encoding. Magn Reson Med 2017;77(5):1786-1796.
    
24. Zhang T, Chen L, Huang J, Li J, Cai S, Cai C, Chen Z. Ultrafast multi-slice spatiotemporally encoded MRI with slice-selective dimension segmented. J Magn Reson 2016;269:138-145.
    
25. Wei ZL, Yang J, Chen YH, Chen L, Cao SH, Cai SH, Lin YQ, Chen Z. Ultrafast multidimensional nuclear magnetic resonance technique: A proof of concept based on inverse-k-space for convenient and efficient performance. Applied Physics Letters 2016;108(8):084102.
    
26. Li A-H, Lü M, Yang J, Chen L, Cui X, Sun Z. Upconversion-luminescent/magnetic dual-functional sub-20-nm core-shell SrF_2: Yb, Tm@ CaF_2: Gd heteronanoparticles. Dalton Trans 2016;45:5800-5807.
    
27. Li J, Zhang M, Chen L, Cai C, Sun H, Cai S. Reduced field-of-view imaging for single-shot MRI with an amplitude-modulated chirp pulse excitation and Fourier transform reconstruction. Magn Reson Imaging 2015;33(5):503-515.
    
28. Li J, Chen L, Cai S, Cai C, Zhong J, Chen Z. Imaging with referenceless distortion correction and flexible regions of interest using single-shot biaxial spatiotemporally encoded MRI. NeuroImage 2015;105(1):93-111.
    
29. Li J, Cai CB, Chen L, Chen Y, Qu XB, Cai SH. Flexible reduced field of view magnetic resonance imaging based on single-shot spatiotemporally encoded technique. Chinese Physics B 2015;24(10):108703.
    
30. Chen Y, Li J, Qu X, Chen L, Cai C, Cai S, Zhong J, Chen Z. Partial Fourier transform reconstruction for single-shot MRI with linear frequency-swept excitation. Magn Reson Med 2013;69(5):1326-1336.
    

Conference abstracts

1. Chen L, Schar M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss RG, van Zijl PCM, Xu J. High-resolution phosphocreatine mapping using artificial neural network-based CEST MRI at 3T: A validation study. ISMRM 28th Annual Meeting & Exhibition, 08-14 August 2020. (Magna Cum Laude Merit Award).
   
2. Chen L, Wei Z, Chan KW, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PCM, Li T, Xu J. Functioning of the glucose transporter and glymphatic systems in the tauopathy AD mouse brain studied by onVDMP MRI and D-glucose infusion. ISMRM 28th Annual Meeting & Exhibition, 08-14 August 2020.
3. Chen L, Liu J, Chu C, Yadav N, Xu J, Pearl M, Walczak P, van Zijl PCM, Janowski M, Liu G. Deuterium oxide as a black water contrast medium for real-time MRI-guided endovascular neurointervention ISMRM 28th Annual Meeting & Exhibition, 08-14 August 2020.
4. Chen L, Schär M, Chan KWY, Huang J, Qin Q, Weiss RG, van Zijl PCM, Xu J. High-resolution phosphocreatine mapping of human skeletal muscle by artificial neural network-based chemical exchange saturation transfer MRI at 3T. ISMRM 27th Annual Meeting & Exhibition, Montreal, 11-16 May 2019. (Summa Cum Laude Merit Award).
   
5. Chen L, Barker PB, Weiss RG, van Zijl PCM, Xu J. Creatine and phosphocreatine mapping by polynomial and Lorentzian line-shape (PLOF) CEST method. ISMRM 27th Annual Meeting & Exhibition, Montreal, 11-16 May 2019.
6. Chen L, Wei Z, Xu X, Li Y, Cai S, Liu G, Lu H, Barker PB, Weiss RG, van Zijl PCM, Xu J. High-resolution total Creatine mapping of the mouse brain at 11.7T using CEST ISMRM 26th Annual Meeting & Exhibition, Paris, 16-21 June 2018.
7. Chen L, Wei Z, Chan KWY, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J. Protein Aggregation in Mouse Brain with Alzheimer’s Disease Revealed by Saturation Transfer MRI. ISMRM 26th Annual Meeting & Exhibition, Paris, 16-21 June 2018.
8. Chen L, Xu X, Zeng H, Chan KWY, Yadav N, Cai S, Schunke KJ, Faraday N, van Zijl PCM, Xu J. Separating out Fast and Slow Chemical Exchange Using Off-resonance Variable Delay Multiple Pulse (VDMP) ISMRM 25th Annual Meeting & Exhibition, Honolulu, 22-27 April 2017.
9. Chen L, Cai S, Cai C, Chen Z. Variable density spiral sampling and reconstruction for spatiotemporally encoded single-shot MRI. ISMRM 24th Annual Meeting & Exhibition, Singapore, 07-13 May 2016.
10. Chen L, Cai S, Cai C, Chen Z. Super-resolved enhancing and edge deghosting for spatiotemporally encoded single-shot MRI. ISMRM 23rd Annual Meeting & Exhibition, Toronto, Ontario, Canada, 30 May-5 June 2015.
11. Chen L, Cai S, Cai C. Spiral Sampling for Spatiotemporally Encoded Single-Shot MRI. International Society of Magnetic Resonance, Shanghai, China, 16-21 August 2015; (Best Poster Award).
    
12. Chen L, Cai C, Cai S, Chen Z. Accelerating MRI by quadratic phase encoding. ISMRM 23rd Annual Meeting & Exhibition, Toronto, Ontario, Canada, 30 May-5 June 2015.
13. Chen L, Cai C, Cai S, Chen Z. An artifacts reducing approach for fat-water separation in spatiotemporally encoded single-shot MRI. ISMRM 22nd Annual Meeting & Exhibition, Milan, Italy, 10 - 16 May 2014.

Patents

1. Cai S, Chen L, Li J, Huang J, Zhang T, Cai C. Variable density sampling and non-Cartesian super-resolved reconstruction for spatiotemporally encoded single-shot MRI. China Patent, No ZL201510269980X.
   
2. Cai S, Li J, Cai C, Chen L, Chen Z. Flexible reduced field of view magnetic resonance imaging based on single-shot spatiotemporally encoded technique. China Patent, No ZL2014100574720.
   
3. Cai S, Li J, Cai C, Chen L, Chen Z. Imaging with referenceless distortion correction using single-shot biaxial spatiotemporally encoded MRI. China Patent, No ZL2014100575390.
   
4. Cai S, Zhang T, Cai C, Li J, Chen L, Huang J. Ultrafast multi-slice spatiotemporally encoded MRI with slice-selective dimension segmented. China Patent, No 2015108879878.
   
5. Cai S, Huang J, Cai C, Chen L, Liao P. An Efficient Water-Fat Separation Reconstruction Method Based on Single-Shot Spatiotemporally Encoded MRI. China Patent, No 2017102880508.